Cookie Policy

  1. What is a cookie?

Cookies are small text files that a website may place or store on your internet device when you visit a website or webpage, commonly used to collect, or read personal data. These cookies gather information about the use of a website or enable the website to recognise the user as an existing customer when they return to it at a later time, and so there are different types of cookies.

In most circumstances, this information does not directly identify you, but merely provides a more personalized web experience. Because we respect your privacy, we request your consent to accept all or some of these cookies. However, you should know that blocking any of these cookies might impact your browsing experience.

You have the right reconsider your decision at any other time.

  1. Types of cookies

There are three different ways to classify cookies: duration, purpose, and origin.

2.1 Duration cookies

Session cookies, also known as temporary cookies, help the website to recognise users and the information they provide when they navigate through it. These cookies only last as long as your online session, and are deleted from the internet device when you close your browser. Session cookies do not contain an expiration date.

Permanent cookies, also known as persistent cookies, stay on your internet device after your browser has been closed and last for a time specified in the cookie. These are usually used to retain login information, or personal website preferences, so that users don’t need to re-enter this information every time they use the website.

Permanent cookies have an expiration date.

2.2 Origin of cookies

First-party cookies are those which are placed on the internet device directly by the website you are visiting.

Third-party cookies, are placed on the internet device by a third party, such as an advertising or analytical system.

2.3 Purpose cookies

Strictly necessary cookies, are required for the website to function and cannot be switched off in our systems. These are usually set in response to actions made by the user, requesting specific services, such as online shopping.  You can always set your browser to block or alert you about these cookies, but if blocked, the website may not work properly. These cookies do not store any personal identifiable information (PII), and are first-party cookies and usually session, but could also be persistent.

Preference cookies, also known as functional cookies, allow the website to retain user preferences, like logging credentials, language, or regional preferences. These cookies do not store any personal identifiable information (PII). First-party cookies and persistent.

Statistical cookies, also known as performance cookies, collect information from the user browsing experience, such as the web pages which have been visited, and the links which have been clicked. This data is aggregated and anonymized, which is then stored in a way so that the user may never be identified. These cookies are persistent and originate from a third-party, such as Google analytics cookies, and are either used to distinguish users, or to continue an online session.

Marketing cookies, also known as targeting cookies, may be set on the internet device through the website by advertising partners, and are usually used to build a personal profile of interests, and target relevant adverts based on this profile. Target cookies do not store personal identifiable information (PII) and are only based on uniquely identifying your browser and the internet device. Persistent and third-party origin.

  1. Your consent to the use of cookies

The use of cookies is subject to your consent, you can update or change your choices for our website at any time by clicking on the Cookie Icon.

You have a variety of tools to control cookies and similar technologies, including browser controls to block and delete cookies. Please look at your browser for instructions on these functions.

  1. How to Contact Us

If you have any questions, comments, or concerns about this Cookie Policy please use the contact information included within our Privacy Policy.

  1. Changes to This Cookie Policy

If this Cookie Policy changes, the revised policy will be posted on this site.

Reference:, cookies, the GDPR and the ePrivacy Directive

Last update: March 2023

Indication & Important Safety Information

CUVRIOR is a copper chelator indicated for the treatment of adult patients with stable Wilson Disease who are de-coppered and tolerant to penicillamine. Please see full Prescribing Information.
Important Safety Information
CUVRIOR is a copper chelator indicated for the treatment of adult patients with stable Wilson Disease who are de-coppered and tolerant to penicillamine.


  • CUVRIOR is contraindicated in patients with hypersensitivity to trientine or to any of the excipients in CUVRIOR.


  • Potential for Worsening of Clinical Symptoms at Initiation of Therapy, including neurological deterioration, may occur at the beginning of CUVRIOR therapy due to mobilization of excess stores of copper. Adjust the dosage or discontinue therapy if clinical condition worsens. Evaluate serum non-ceruloplasmin copper (NCC) levels or 24-hour urinary copper excretion (UCE) when initiating treatment, after 3 months, and approximately every 6 months thereafter.
  • Copper Deficiency may develop following treatment with CUVRIOR. Periodic monitoring is required.
  • Iron Deficiency may develop following treatment with CUVRIOR. If iron deficiency develops, a short course of iron supplementation may be given.
  • Hypersensitivity Reactions, characterized by rash, have been reported with the use of trientine. Rash was reported in 12% (3/26) of CUVRIOR-treated patients, and one patient discontinued treatment due to rash. If rash or other hypersensitivity reaction occurs, consider discontinuing CUVRIOR.


The most common adverse reactions (>5%) are abdominal pain, change of bowel habits, rash, alopecia, and mood swings.


  • Mineral Supplements (e.g. iron, zinc, calcium, magnesium): Avoid concomitant use. If concomitant use is unavoidable, take CUVRIOR at least 2 hours before or 2 hours after iron and take CUVRIOR at least 1 hour before or 2 hours after other mineral supplements.
  • Other Drugs for Oral Administration: Take CUVRIOR at least 1 hour apart from any other oral drug

Please see full Prescribing Information

To report SUSPECTED ADVERSE REACTIONS, call Orphalan at 1-800-961-8320 or FDA at 1-800-FDA-1088 or